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Publications
Posters Presented at 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) / 27th International Congress of Chemotheraphy (ICC), May 7-10, 2011
In a phase 2 complicated skin and soft tissue infections trial, outcomes assessed early in the course of therapy were consistent with outcomes 10-17 days after completing therapy with either omadacycline (OMC; PTK796) or linezolid, Poster P1528
Comparative efficacy of omadacycline (PTK796) in a lethal Streptococcus pneumoniae and Staphylococcus aureus pneumonia model, Poster P1074
In vitro activity of omadacycline (PTK796) in broth plus lung surfactant or human serum, Poster P1141
Posters Presented at 50th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), September 12-15, 2010
Efficacy of PTK796 in a Rat MRSA Infected Endocarditis (IE) Model, Poster B-069
Studies on the Mechanism of Resistance to PTK796 in Pseudomonas aeruginosa and Klebsiella pneumonia, Poster C1-1413
In Vitro Evaluation of PTK 0796 Activity Tested against Staphylococcus aureus, Including Hospital- and Community-Associated MRSA Strains from the USA and Europe, Poster E-1569
Antimicrobial Activity of PTK 0796 Tested against Gram-Positive Organisms Causing Bloodstream Infections in 2009, Poster E-1588
Pharmacokinetics of Intravenous and Oral PTK796, A New Aminomethylcycline Antibiotic, Poster K-124
Identification and Susceptibility of Pathogens Isolated from Patients with Complicated Skin and Skin Structure Infections (cSSSI): Results of a PTK0796 (PTK) Phase 2 Clinical Trial, Poster L1-1760
Poster Presented at Annual European League Against Rheumatism (EULAR) Congress, June 10-13, 2009
Inhibition of Murine Collagen-Induced Arthritis by Non-Antibacterial Tetracycline Derivatives
Posters Presented at 48th Annual Interscience Conference on Antimicrobial
Agents and Chemotherapy (ICAAC), October 25-28, 2008
Safety and Efficacy of PTK 0796: Results of the Phase 2 Study in
Complicated Skin and Skin Structure Infections Following IV and Oral Step Down
Therapy, Poster L-1515b
Efficacy of MAR Inhibitors in a Pseudomonas aeruginosa Pneumonia Model, Poster
F1-3958
Poster Presented at 15th International Inflammation Research Association Conference, September 21-24, 2008
Therapeutic
Inhibition of Murine Collagen-Induced Arthritis by Non-Antibacterial
Derivatives of Minocycline
Poster Presented at 60th Annual Meeting of the American Academy of Neurology, April 12-19, 2008
A Tetracycline That Corrects SMN2 Splicing for Potential Treatment of Spinal Muscular Atrophy (SMA)
Poster Presented at 47th Annual Interscience Conference on Antimicrobial
Agents and Chemotherapy (ICAAC), September 18, 2007
A Novel
Anti-virulence Approach for Treatment of Pneumonia Caused by Pseudomonas
aeruginosa, Poster F2-968a
Poster Presented at 107th General Meeting of the American Society for
Microbiology (ASM), May 22, 2007
Small Molecule Inhibitors of Yersinia pseudotuberculosis Transcription Factor
LcrF (VirF) Attenuate Virulence and Limit Infection in a Murine Pneumonia
Model, Poster A-030
Posters Presented at 46th Annual Interscience Conference on Antimicrobial
Agents and Chemotherapy (ICAAC), September 30, 2006
Antistaphylococcal
Activity of MK-2764 / PTK 0796 Compared to Other Agents, Poster F1-1971
In Vitro
Activity of MK-2764 / PTK 0796 Against Legionella spp., Poster F1-1972
Pharmacokinetic/Pharmacodynamic
Profile of MK-2764 / PTK 0796 against S. pneumoniae in a Murine Pneumonia
Model, Poster F1-1973
In Vivo
Pharmacodynamics of MK-2764 / PTK 0796 Against Various Gram-positive and
Gram-negative Bacteria in the Thighs of Neutropenic and Normal Mice, Poster
F1-1974
Posters Presented at 43rd Annual Interscience Conference on Antimicrobial
Agents and Chemotherapy (ICAAC), September 15, 2003
In Vitro
Activity of BAY 73-6944/PTK 0796 Against Gram-Positive and Gram-Negative
Organisms, Poster F-754
Evaluation of
BAY 73-6944/PTK 0796 in Experimental Models of Infections Caused by
Gram-Positive and Gram-Negative Pathogens, Poster F-757
The Efficacy of
BAY 73-6944/PTK 0796 in Murine Models of Streptococcus pneumoniae Infections,
Poster F-758
BAY 73-6944/PTK
0796: In Vitro Potency and Spectrum of Activity Compared to Ten Other
Antimicrobial Compounds, Poster F-753
BAY 73-6944/PTK
0796: Effects of Environmental Variation on MICs and Confirmation of Disk Mass,
Poster F-756
Pharmacokinetics
of BAY 73-6944/PTK 0796 in Mouse, Rat and Cynomolgus Monkey, Poster F-759
The Activity of
BAY 73-6944/PTK 0796 Against Tetracycline Resistance, Poster F-752
In Vitro
Assessment of Plasma Protein Binding and Metabolic Stability of BAY 73-6944/PTK
0796, Poster F-760
The Mechanism
of Action of BAY 73-6944/PTK 0796, Poster F-751
BAY
73-6944/PTK 0796 and other Novel Tetracycline Derivatives Exhibiting Potent in
vitro and in vivo Activities Against Antibiotic Resistant Gram-Positive
Bacteria, Poster F-755
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