Paratek Publications

ICCAC - Chicago, IL - September 2003

• In Vitro Activity of PTK0796 Against Gram-Positive And Gram-Negative Organisms
• The Efficacy of PTK 0796 (BAY 73-6944) in Murine Models of Streptococcus pneumoniae Infections
• Evaluation of PTK 0796 (BAY 73-6944) in Experimental Models of Infections Caused by Gram-Positive and Gram-Negative Pathogens
• PTK 0796 (BAY 73-6944): In Vitro Potency and Spectrum of Activity Compared to Ten Other Antimicrobial Compounds
• PTK 0796 (BAY 73-6944): Effects of Environmental Variation on MICs and Confirmation of Disk Mass
• Pharmacokinetics of PTK 0796 (BAY 73-6944) in Mouse, Rat, and Cynomolgus Monkey
• In Vitro Assessment of Plasma Protein Binding and Metabolic Stability of PTK 0796 (BAY 73-6944)
• The Mechanism of Action of PTK 0796 (BAY 73-6944)
• The Activity of PTK 0796 (BAY 73-6944) Against Tetracycline Resistance
• PTK 0796 (BAY 73-6944) and Other Novel Tetracycline Derivatives Exhibiting Potent In vitro and In vivo Activities Against Antibiotic Resistant Gram-Positive Bacteria

ECCMID - Prague, Czechoslovakia - May 2004

• Activity of BAY 73-7388, a novel aminomethylcycline, and other novel antibiotic classes against resistant bacteria in vitro
• Potent activity of BAY 73-7388, a novel aminomethylcycline, against susceptible and resistant Gram-positive and Gramnegative organisms
• BAY 73-7388, a novel aminomethylcycline, exhibits potent efficacy in pulmonary murine models of infection
• BAY 73-7388 is highly efficacious in animal models of intraabdominal infections caused by a range of aerobic and anaerobic organisms, including VRE
• BAY 73-7388 demonstrates greater activity than linezolid in a range of murine models of skin and soft tissue infection
• Superior efficacy of BAY 73-7388, a novel aminomethylcycline, compared with linezolid and vancomycin in murine sepsis caused by susceptible or multiresistant staphylococci
• BAY 73-7388, a novel aminomethylcycline, is highly active in vivo in a murine model of pneumococcal pneumonia

Neuroscience Presentation on Non-Antibacterial Tetracyclines in EAE

• Abstract

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